Receptor Family, Induces Monocyte Activation CD137 (ILA/4-1BB), a Member of the TNF
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منابع مشابه
Identification of CD137 as a potent monocyte survival factor.
CD137 (ILA/4-1BB), a member of the tumor necrosis factor (TNF) receptor family, promotes adherence and prolongs survival of human peripheral monocytes. It induces a strong expression of macrophage colony-stimulating factor (M-CSF), an essential monocyte survival factor. Monocyte survival induced by CD137 is primarily mediated by M-CSF and to a lesser extent by granulocyte-macrophage colony-stim...
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4-1BB ligand (4-1BBL) is a member of the tumor necrosis factor (TNF) family expressed on activated antigen-presenting cells. Its receptor, 4-1BB, is a member of the TNF receptor family expressed on activated CD4 and CD8 T cells. We have produced a soluble form of 4-1BBL using the baculovirus expression system. When coimmobilized on plastic with anti-CD3, soluble 4-1BBL induces interleukin (IL)-...
متن کاملCD137 induces proliferation and endomitosis in monocytes.
Peripheral monocytes are short-lived and are replenished from hematopoietic stem cells whose proliferation is believed to be confined to the bone marrow. Human peripheral monocytes are assumed not to be able to proliferate. In this study we show that CD137 (ILA/4-1BB), a member of the tumor necrosis factor receptor family, induces a widespread and profound proliferation of human peripheral mono...
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Peripheral monocytes are short-lived and are replenished from hematopoietic stem cells whose proliferation is believed to be confined to the bone marrow. Human peripheral monocytes are assumed not to be able to proliferate. In this study we show that CD137 (ILA/4-1BB), a member of the tumor necrosis factor receptor family, induces a widespread and profound proliferation of human peripheral mono...
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CD137 (ILA/4-1BB), a member of the tumor necrosis factor receptor family, and its ligand are expressed on activated T lymphocytes and on antigen-presenting cells, respectively. Via bidirectional signal transduction, this receptor-ligand system regulates the activation, proliferation, and survival of T and B lymphocytes and monocytes. We used immunohistochemical studies on human tissue samples t...
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